CHARACTERISTICS AND ANALYTICAL METHODS OF MANNITOL: AN UPDATE

Mannitol is an organic compound, a widely distributed natural sugar alcohol in nature. It found various plant species and produced by many microorganisms. about 50% as sweet sucrose, has low glycaemic index inert nature, making it suitable to be used food products. osmotic diuretic administering through the iv route having clinical usages one of well-known excipients different types formulations. This also increase dissolution drugs solubility problems. can drug excipient. The goal this work was summarize important physicochemical properties, mechanism action, production, applications, incompatibilities, polymorphism, particularly analytical methodologies published last five decades for quantification. Relevant articles related methods were identified search English-language literature indexed Medline, PubMed, ScienceDirect google scholar from 1970 till date. terms benign estimation mannitol, determination HPLC Spectrophotometry method mannitol. described USP, IP, BP are described. presented review outlines further scope research field development methods.